Agenda for Future Research in Melasma: QUO VADIS?
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چکیده
Copyright: © 2014 Panda S, et al. the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Our understanding of melasma as a disease has undergone a radical shift in the past decade or two [1]. The landmark paper by Sanchez et al. published in 1981 first provided for a structured model of the disease based on clinical, light microscopic, ultrastructural, and immunofluorescence findings [2]. The rigid structural model proposed at that time dividing melasma into epidermal, dermal and mixed subtypes has, of late, been questioned by studies employing modern investigational techniques, viz., in vivo Reflectance Confocal Microscopy (RCM), Immunohistochemistry (IHC), and electron microscopy. Thus, currently melasma is viewed as being much more than just about the abnormal deposition of melanin and altered disposition of melanocytes. Evidence of dynamic interaction of melanocytes with a number of cellular elements, including keratinocytes, dermal fibroblasts and vascular endothelium, and induction of epithelial-mesenchymal transition [3] have been recently found in melasma, turning its pathophysiology into a highly dynamic and complex process.
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تاریخ انتشار 2014